Paradoxical second-meal phenomenon in the acute post-exercise period

Gonzalez, Javier (2014) Paradoxical second-meal phenomenon in the acute post-exercise period. Nutrition, 30 (9). pp. 961-967. ISSN 08999007

PDF (Accepted author manuscript)
Gonzalez_J_-_Paradoxical_Second_meal_phenomenon_in_the_acute_post_exercise_period.pdf - Accepted Version

Download (409kB) | Preview
Official URL:


Attenuating blood glucose excursions in the postprandial state has the capacity to reduce the risk of cardiovascular disease, type 2 diabetes and mortality, even in apparently healthy populations. Almost a century ago it was reported that oral glucose tolerance is improved by prior glucose consumption. This was termed the second-meal phenomenon and is also seen with consumption of mixed-macronutrient containing meals. In this context a number of mechanisms probably contribute to the attenuation of glycemia, including: gastric emptying, early-phase insulin secretion, hepatic glucose output and muscle glucose uptake. More recently, a paradoxical second-meal phenomenon has been observed in the immediate post-exercise period whereby prior meal consumption deteriorated glucose tolerance. The mechanisms regulating the post-exercise second-meal phenomenon are less clear, but are likely to involve an increase in intestinal absorption, greater hepatic glucose output, and under circumstances of muscle-damage, reductions in muscle glucose uptake. Further work is required to confirm these mediating factors and to characterize the time-course of this paradox, which is likely to only exist within the first 4 h following exercise. Critically, this acute post-exercise phenomenon should be maintained in the perspective of the benefits of chronic exercise training, which for the majority of individuals improves glycemic control and reduces many health risks including those associated with exaggerated postprandial glycemia.

Item Type: Article
Uncontrolled Keywords: exercise, fatty acids, glucose, insulin, metabolism, postprandial, type 2 diabetes
Subjects: C600 Sports Science
Department: Faculties > Health and Life Sciences > Sport, Exercise and Rehabilitation
Depositing User: Becky Skoyles
Date Deposited: 17 Dec 2013 09:03
Last Modified: 17 Dec 2023 14:46

Actions (login required)

View Item View Item


Downloads per month over past year

View more statistics