Schneider, Kathrin, Rose, Ilona, Vikineswary, Sabaratnam, Jones, Amanda, Goodfellow, Michael, Nicholson, Graeme, Beil, Winfried, Süssmuth, Roderich and Fiedler, Hans-Peter (2007) Nocardichelins A and B, new siderophores from Nocardia strain Acta 3026. Journal of Natural Products, 70 (6). pp. 932-935. ISSN 0163-3864
Full text not available from this repository. (Request a copy)Abstract
An actinomycete, strain Acta 3026, isolated from mangrove soil was characterized and found to belong to the genus Nocardia. The strain produces two new cytotoxic metabolites, nocardichelins A (1) and B (2). Each of the compounds strongly inhibited human cell lines from gastric adenocarcinoma, breast carcinoma, and hepatocellular carcinoma with GI50 values in a low micromolar to nanomolar range. The structural characterization of the compounds was performed by mass spectrometry and NMR spectroscopy. The nocardichelins represent a new group of siderophores that combine the structural elements of mycobactin-type siderophores from mycobacteria and hydroxamate-type siderophores (desferrioxamine B) produced by streptomycetes. The chromazurol S assay, characteristic for iron(III) complexation, was positive, confirming the role as a siderophore.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | siderophores, nocardia |
| Subjects: | B200 Pharmacology, Toxicology and Pharmacy B300 Complementary Medicine |
| Department: | Faculties > Health and Life Sciences > Applied Sciences |
| Depositing User: | EPrint Services |
| Date Deposited: | 29 May 2009 14:25 |
| Last Modified: | 12 Oct 2019 17:30 |
| URI: | http://nrl.northumbria.ac.uk/id/eprint/1637 |
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