Are We Under-Estimating the Association Between Autism Symptoms?: The Importance of Considering Simultaneous Selection When Using Samples of Individuals Who Meet Diagnostic Criteria for an Autism Spectrum Disorder

Murray, Aja Louise, McKenzie, Karen, Kuenssberg, Renate and O’Donnell, Michael (2014) Are We Under-Estimating the Association Between Autism Symptoms?: The Importance of Considering Simultaneous Selection When Using Samples of Individuals Who Meet Diagnostic Criteria for an Autism Spectrum Disorder. Journal of Autism and Developmental Disorders, 44 (11). pp. 2921-2930. ISSN 0162-3257

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Abstract

The magnitude of symptom inter-correlations in diagnosed individuals has contributed to the evidence that autism spectrum disorders (ASD) is a fractionable disorder. Such correlations may substantially under-estimate the population correlations among symptoms due to simultaneous selection on the areas of deficit required for diagnosis. Using statistical simulations of this selection mechanism, we provide estimates of the extent of this bias, given different levels of population correlation between symptoms. We then use real data to compare domain inter-correlations in the Autism Spectrum Quotient, in those with ASD versus a combined ASD and non-ASD sample. Results from both studies indicate that samples restricted to individuals with a diagnosis of ASD potentially substantially under-estimate the magnitude of association between features of ASD.

Item Type:	Article
Additional Information:	Published online 5-6-2014 ahead of print
Uncontrolled Keywords:	Autism spectrum disorder, Range restriction, Fractionable triad, Simultaneous selection, Sampling
Subjects:	C800 Psychology
Department:	Faculties > Health and Life Sciences > Psychology
Depositing User:	Karen McKenzie
Date Deposited:	12 Nov 2014 16:18
Last Modified:	12 Oct 2019 17:26
URI:	http://nrl.northumbria.ac.uk/id/eprint/18043

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