Experimental design approach for supercritical fluid extraction

Kane, Mark, Dean, John, Hitchen, Steven, Dowle, Christopher and Tranter, Roy (1993) Experimental design approach for supercritical fluid extraction. Analytica Chimica Acta, 271 (1). pp. 83-90. ISSN 0003-2670

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Abstract

Experimental design with multilinear regression has been used to examine the relative contribution of the main experimental variables during supercritical fluid extraction. Six steroidal compounds of various solubilities in supercritical CO2 were considered. The results indicate that the density of the supercritical fluid has the greatest effect on the solubilisation and transfer of steroid from extraction cell to collection device. The minimum number of cell volumes of supercritical CO2 required for effective extraction was experimentally determined.

Item Type:	Article
Uncontrolled Keywords:	Carbon dioxide; Extraction; Multilinear regression; Steroid; Supercritical fluid extraction
Subjects:	F100 Chemistry
Department:	Faculties > Health and Life Sciences > Applied Sciences
Depositing User:	Becky Skoyles
Date Deposited:	17 Feb 2015 16:35
Last Modified:	12 Oct 2019 17:29
URI:	http://nrl.northumbria.ac.uk/id/eprint/18648

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