Determination of octanol-water partition coefficients using gradient liquid chromatography

Makovskaya, Valeria Vladimirovna, Dean, John, Tomlinson, William, Hitchen, Steven and Comber, Michael (1995) Determination of octanol-water partition coefficients using gradient liquid chromatography. Analytica Chimica Acta, 315 (1-2). pp. 183-192. ISSN 0003-2670

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The use of liquid chromatography to estimate octanol-water partition coefficients, log k(ow), has been demonstrated. The capacity factor with a mobile phase of 100% water, k(w), has been found to be a useful chromatographic parameter. Values of k(w) were derived from a computer software package (Hipac-G), designed for optimization and simulation of gradient LC systems. The chromatographic parameter, k(w) correlates well with both literature and isocratic LC-generated log k(ow) values. The gradient LC method could be extended to a wider range of test compounds.

Item Type: Article
Uncontrolled Keywords: Environmental analysis; Liquid chromatography; Octanol-water partition coefficient
Subjects: F100 Chemistry
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Becky Skoyles
Date Deposited: 17 Feb 2015 14:39
Last Modified: 12 Oct 2019 17:29

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