Prevalence of Helicobacter pylori in patients with gastro-oesophageal reflux disease: Systematic review

Raghunath, Anan, Hungin, Pali, Wooff, David and Childs, Sue (2003) Prevalence of Helicobacter pylori in patients with gastro-oesophageal reflux disease: Systematic review. British Medical Journal, 326 (7392). pp. 737-739. ISSN 0959 8146

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Abstract

Objectives: To ascertain the prevalence of Helicobacter pylori in patients with gastro-oesophageal reflux disease and its association with the disease. Design: Systematic review of studies reporting the prevalence of H pylori in patients with and without gastro-oesophageal reflux disease. Data sources: Four electronic databases, searched to November 2001, experts, pharmaceutical companies, and journals. Main outcome measure: Odds ratio for prevalence of H pylori in patients with gastro-oesophageal reflux disease. Results: 20 studies were included. The pooled estimate of the odds ratio for prevalence of H pylori was 0.60 (95% confidence interval 0.47 to 0.78), indicating a lower prevalence in patients with gastro-oesophageal reflux disease. Substantial heterogeneity was observed between studies. Location seemed to be an important factor, with a much lower prevalence of H pylori in patients with gastro-oesophageal reflux disease in studies from the Far East, despite a higher overall prevalence of infection than western Europe and North America. Year of study was not a source of heterogeneity. Conclusion: The prevalence of H pylori infection was significantly lower in patients with than without gastro-oesophageal reflux, with geographical location being a strong contributor to the heterogeneity between studies. Patients from the Far East with reflux disease had a lower prevalence of H pylori infection than patients from western Europe and North America, despite a higher prevalence in the general population.

Item Type:	Article
Subjects:	B900 Others in Subjects allied to Medicine
Department:	Faculties > Engineering and Environment > Mathematics, Physics and Electrical Engineering
Depositing User:	Becky Skoyles
Date Deposited:	12 Feb 2015 11:19
Last Modified:	12 Oct 2019 22:54
URI:	http://nrl.northumbria.ac.uk/id/eprint/19460

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