Graf, Ellen, Schneider, Kathrin, Nicholson, Graeme, Ströbele, Markus, Jones, Amanda, Goodfellow, Michael, Beil, Winfried, Süssmuth, Roderich and Fiedler, Hans-Peter (2007) Elloxazinones A and B, new aminophenoxazinones from Streptomyces griseus Acta 2871. Journal of Antibiotics, 60. pp. 277-284. ISSN 0021-8820
Full text not available from this repository. (Request a copy)Abstract
Two new aminophenoxazinone compounds with antitumor activity, elloxazinone A and B, were isolated from the culture filtrate of Streptomyces griseus Acta 2871. Their chemical structures were determined by mass spectrometry, NMR spectroscopy and X-ray analysis. Elloxazinones A and B showed a moderate inhibition of the proliferation of human cells from gastric adenocarcinoma in vitro but a strong inhibition of hepatocellular carcinoma cells whereas elloxazinone B strongly inhibited the proliferation of human breast carcinoma cells.
| Item Type: | Article |
|---|---|
| Subjects: | A100 Pre-clinical Medicine C700 Molecular Biology, Biophysics and Biochemistry |
| Department: | Faculties > Health and Life Sciences > Applied Sciences |
| Depositing User: | EPrint Services |
| Date Deposited: | 29 May 2009 13:38 |
| Last Modified: | 12 Oct 2019 17:30 |
| URI: | http://nrl.northumbria.ac.uk/id/eprint/2050 |
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