A framework for density weighted kernel fuzzy c-Means on gene expression data

Wang, Yu, Angelova, Maia and Zhang, Yang (2013) A framework for density weighted kernel fuzzy c-Means on gene expression data. In: Proceedings of The Eighth International Conference on Bio-Inspired Computing: Theories and Applications (BIC-TA), 2013. Advances in Intelligent Systems and Computing, 212 . Springer, pp. 453-461. ISBN 978-3-642-37501-9

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Official URL: http://dx.doi.org/10.1007/978-3-642-37502-6_54


Clustering techniques have been widely used for gene expression data analysis. However, noise, high dimension and redundancies are serious issues, making the traditional clustering algorithms sensitive to the choice of parameters and initialization. Therefore, the results lack stability and reliability. In this paper, we propose a novel clustering method, which utilizes the density information in the feature space. A cluster center initialization method is also presented which can highly improve the clustering accuracy. Finally, we give an investigation to the parameters selection in Gaussian kernel. Experiments show that our proposed method has better performance than the traditional ones.

Item Type: Book Section
Uncontrolled Keywords: fuzzy clustering, gene expression data, parzen density estimation
Subjects: G100 Mathematics
G400 Computer Science
Department: Faculties > Engineering and Environment > Mathematics, Physics and Electrical Engineering
Depositing User: Becky Skoyles
Date Deposited: 19 Jan 2015 13:54
Last Modified: 12 Oct 2019 22:26
URI: http://nrl.northumbria.ac.uk/id/eprint/20802

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