A Cellular Automaton Model of the Effects of Maspin on Cell Migration

Al-Mamun, Mohammad, Hossain, Alamgir, Alam, Muhammad and Bass, Rosemary (2013) A Cellular Automaton Model of the Effects of Maspin on Cell Migration. In: 7th International Conference on Practical Applications of Computational Biology & Bioinformatics. Springer, London, pp. 53-60. ISBN 978-3-319-00577-5

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Abstract

Maspin (Mammary Serine Protease Inhibitor) is a non-inhibitory serpin with multiple cellular effects that is a type II tumour metastasis suppressor. Maspin has been shown to reduce cell migration, invasion, proliferation and angiogenesis, and increase apoptosis and adhesion. In this paper, we report the development of a mathematical model of the effects of maspin on cellular proliferation and migration. An artificial neural network has been used to model the unknown cell signalling to determine the cells fate. Results show that maspin reduces migration by between 10-35%; confirmed by published in vitro data. From our knowledge, this is the first attempt to model maspin effects in a computational model to verify in vitro data. This will provide new insights into to the tumour suppressive properties of maspin and inform the development of novel cancer therapy. © Springer International Publishing Switzerland 2013.

Item Type:	Book Section
Uncontrolled Keywords:	Cell migration, Maspin, mathematical model, neural network, Serpin
Subjects:	C900 Others in Biological Sciences G400 Computer Science
Department:	Faculties > Health and Life Sciences > Applied Sciences Faculties > Engineering and Environment > Computer and Information Sciences
Depositing User:	Becky Skoyles
Date Deposited:	06 Jan 2015 13:18
Last Modified:	12 Oct 2019 18:28
URI:	http://nrl.northumbria.ac.uk/id/eprint/20803

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