Different polyketide folding modes converge to an identical molecular architecture

Bringmann, Gerhard, Noll, Torsten, Gulder, Tobias, Grune, Matthias, Dreyer, Michael, Wilde, Christopher, Pankewitz, Florian, Hilker, Monika, Payne, Gail, Jones, Amanda, Goodfellow, Michael and Fiedler, Hans-Peter (2006) Different polyketide folding modes converge to an identical molecular architecture. Nature Chemical Biology, 2. pp. 429-433. ISSN 1552-4450

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Abstract

Metabolic diversity is being studied intensively by evolutionary biologists, but so far there has been no comparison of biosynthetic pathways leading to a particular secondary metabolite in both prokaryotes and eukaryotes. We have detected the bioactive anthraquinone chrysophanol, which serves as a chemical defense in diverse eukaryotic organisms, in a bacterial Nocardia strain, thereby permitting the first comparative biosynthetic study. Two basic modes of folding a polyketide chain to fused-ring aromatic structures have so far been described1: mode F (referring to fungi) and mode S (from Streptomyces). We have demonstrated that in eukaryotes (fungi, higher plants and insects), chrysophanol is formed via folding mode F. In actinomycetes, by contrast, the cyclization follows mode S. Thus, chrysophanol is the first polyketide synthase product that is built up by more than one polyketide folding mode.

Item Type:	Article
Uncontrolled Keywords:	evolution, prokaryotes, eukaryotic cells
Subjects:	C700 Molecular Biology, Biophysics and Biochemistry
Department:	Faculties > Health and Life Sciences > Applied Sciences
Depositing User:	EPrint Services
Date Deposited:	29 May 2009 12:03
Last Modified:	12 Oct 2019 17:30
URI:	http://nrl.northumbria.ac.uk/id/eprint/2303

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