2-(Nitroaryl)benzothiazole and benzoxazole derivatives as fluorogenic substrates for the detection of nitroreductase activity in clinically important microorganisms

Cellier, Marie, Gignoux, Amandine, James, Arthur, Orenga, Sylvain, Perry, John, Robinson, Shaun, Stanforth, Stephen and Turnbull, Graeme (2015) 2-(Nitroaryl)benzothiazole and benzoxazole derivatives as fluorogenic substrates for the detection of nitroreductase activity in clinically important microorganisms. Bioorganic & Medicinal Chemistry Letters, 25 (24). pp. 5694-5698. ISSN 0960-894X

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Abstract

A series of carboxy-substituted 2-(nitroaryl)benzothiazole derivatives and carboxy-substituted 2-(nitroaryl)benzoxazole derivatives were prepared and evaluated as potential nitroreductase substrates for the purpose of detecting clinically important microorganisms. Several of the substrates produced highly fluorescent colonies with the majority of a panel of 10 Gram-negative bacteria and also with two of a panel of 8 Gram-positive bacteria.

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