Genoketides A1 and A2, new octaketides and biosynthetic intermediates of chrysophanol produced by Streptomyces sp. AK 671

Fiedler, Hans-Peter, Dieter, Anke, Gulder, Tobias, Kajahn, Inga, Hamm, Andreas, Brown, Roselyn, Jones, Amanda, Goodfellow, Michael, Müller, Werner and Bringmann, Gerhard (2008) Genoketides A1 and A2, new octaketides and biosynthetic intermediates of chrysophanol produced by Streptomyces sp. AK 671. Journal of Antibiotics, 61. pp. 464-473. ISSN 0021-8820

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Abstract

The new aromatic polyketides genoketide A1, genoketide A2 and prechrysophanol glucuronide are biosynthetic intermediates of the octaketide chrysophanol. They were isolated from the alkaliphilic strain Streptomyces sp. AK 671 together with the new metabolite chrysophanol glucuronide. The structures of the compounds were elucidated by mass spectrometry and NMR methods. Genoketide A2 exhibited a slight and prechrysophanol glucuronide a more pronounced inhibition of the proliferation of L5178y lymphoma cells.

Item Type:	Article
Uncontrolled Keywords:	Fermentation, Streptomyces
Subjects:	B200 Pharmacology, Toxicology and Pharmacy
Department:	Faculties > Health and Life Sciences > Applied Sciences
Depositing User:	EPrint Services
Date Deposited:	01 Jun 2009 14:34
Last Modified:	12 Oct 2019 17:31
URI:	http://nrl.northumbria.ac.uk/id/eprint/2439

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