Pragmatic lifestyle intervention in patients recovering from colon cancer: a randomized controlled pilot study.

Bourke, Liam, Thompson, Georgia, Gibson, Debra, Daley, Amanda, Crank, Helen, Adam, Ian, Shorthouse, Andrew and Saxton, John (2011) Pragmatic lifestyle intervention in patients recovering from colon cancer: a randomized controlled pilot study. Archives of Physical Medicine and Rehabilitation, 92 (5). pp. 749-755. ISSN 0003-9993

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Abstract

OBJECTIVE

To investigate the feasibility of a pragmatic lifestyle intervention in patients who had recently completed surgery and chemotherapy for colon cancer and to obtain preliminary data of its impact on important health outcomes.

DESIGN

A prospective, randomized, controlled pilot trial.

SETTING

University rehabilitation facility.

PARTICIPANTS

Eighteen (N=18) colon cancer survivors (mean age=69y; range, 52-80y), Dukes stage A to C.

INTERVENTIONS

Participants were randomized 6 to 24 months postoperatively to either a 12-week program of combined exercise and dietary advice or standard treatment.

MAIN OUTCOME MEASURES

Exercise and dietary behavior, fatigue, health-related quality of life (QOL), aerobic exercise tolerance, functional capacity, muscle strength, and anthropometery were assessed at baseline and immediately after the intervention.

RESULTS

Adherences to supervised and independent exercise during the intervention were 90% and 94%, respectively, and there was low attrition (6%). The lifestyle intervention elicited improvements in exercise behavior (P=.068), fatigue (P=.005), aerobic exercise tolerance (P=.010), chair sit-to-stand performance (P=.003), and waist-to-hip ratio (P=.002). A positive change in dietary fiber intake (P=.044) was also observed in the intervention group. No change in QOL was observed (P=.795).

CONCLUSIONS

These preliminary results suggest that a pragmatic lifestyle intervention implemented 6 to 24 months after primary treatment for colon cancer was feasible. We observed a significant impact on dietary behavior, fatigue, aerobic exercise tolerance, functional capacity, and waist-to-hip ratio. These findings need to be confirmed with a larger-scale definitive randomized controlled trial.

Item Type:	Article
Additional Information:	PMID: 21530722
Uncontrolled Keywords:	colonic neoplasms, diet, exercise, fatigue, rehabilitation
Subjects:	A300 Clinical Medicine C600 Sports Science
Department:	Faculties > Health and Life Sciences > Sport, Exercise and Rehabilitation
Depositing User:	Prof John Saxton
Date Deposited:	01 Mar 2016 12:54
Last Modified:	12 Oct 2019 15:29
URI:	http://nrl.northumbria.ac.uk/id/eprint/26211

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