Connective tissue diseases: Nucleosomes and systemic sclerosis

O'Reilly, Steven and van Laar, Jacob (2016) Connective tissue diseases: Nucleosomes and systemic sclerosis. Nature Reviews Rheumatology, 12 (3). pp. 138-139. ISSN 1759-4790

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Abstract

Systemic sclerosis (SSc) is characterized by an abnormal immune response to innocuous antigens that might lead to autoantibody production. New observations suggest that nucleosomes can mediate both IgG production and B-cell proliferation, via Toll-like receptor signalling, and thereby affect the pathogenesis of SSc.
Refers to Yoshizaki, A. et al. Nucleosome in patients with systemic sclerosis: possible association with
immunological abnormalities via abnormal activation of T and B cells. Ann. Rheum. Dis. http://dx.doi.org/10.1136/
annrheumdis-2015-207405

Item Type:	Article
Uncontrolled Keywords:	Clinical epigenetics, Immunopathogenesis, Molecular medicine, Systemic sclerosis
Subjects:	B100 Anatomy, Physiology and Pathology
Department:	Faculties > Health and Life Sciences > Applied Sciences
Depositing User:	Becky Skoyles
Date Deposited:	16 Mar 2016 14:22
Last Modified:	10 Oct 2019 16:46
URI:	http://nrl.northumbria.ac.uk/id/eprint/26368

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