Connective tissue diseases: Nucleosomes and systemic sclerosis

O'Reilly, Steven and van Laar, Jacob (2016) Connective tissue diseases: Nucleosomes and systemic sclerosis. Nature Reviews Rheumatology, 12 (3). pp. 138-139. ISSN 1759-4790

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Systemic sclerosis (SSc) is characterized by an abnormal immune response to innocuous antigens that might lead to autoantibody production. New observations suggest that nucleosomes can mediate both IgG production and B-cell proliferation, via Toll-like receptor signalling, and thereby affect the pathogenesis of SSc.
Refers to Yoshizaki, A. et al. Nucleosome in patients with systemic sclerosis: possible association with
immunological abnormalities via abnormal activation of T and B cells. Ann. Rheum. Dis.

Item Type: Article
Uncontrolled Keywords: Clinical epigenetics, Immunopathogenesis, Molecular medicine, Systemic sclerosis
Subjects: B100 Anatomy, Physiology and Pathology
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Becky Skoyles
Date Deposited: 16 Mar 2016 14:22
Last Modified: 10 Oct 2019 16:46

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