Stroke survivors in low- and middle-income countries: a meta-analysis of prevalence and secular trends

Ezejimofor, Martinsixtus, Chen, Yen-Fu, Kandala, Ngianga-Bakwin, Ezejimofor, Benedeth, Ezeabasili, Aloysius, Stranges, Saverio and Uthman, Olalekan (2016) Stroke survivors in low- and middle-income countries: a meta-analysis of prevalence and secular trends. Journal of the Neurological Sciences, 364. pp. 68-76. ISSN 0022-510X

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To provide an up-to-date estimate on the changing prevalence of stroke survivors, and examines the geographic and socioeconomic variations in low and middle-income countries (LMICs).


We searched MEDLINE, EMBASE, SCOPUS and Web of Science databases and systematically reviewed articles reporting stroke prevalence and risk factors from inception to July 2015. Pooled prevalence estimates and secular trends based on random-effects models were conducted across LMICs, World Bank regions and income groups.


Overall, 101 eligible community-based studies were included in the meta-analysis. The pooled crude prevalence of stroke survivors was highest in Latin America and Caribbean (21.2 per 1000, 95% CI 13.7 to 30.29) but lowest in sub-Saharan Africa (3.5 per 1000, 95% CI 1.9 to 5.7). Steepest increase in stroke prevalence occurred in low-income countries, increasing by 14.3% annually while the lowest increase occurred in lower-middle income countries (6% annually), and for every 10 years increase in participants' mean age, the prevalence of stroke survivors increases by 62% (95% CI 6% to 147%).


The prevalence estimates of stroke survivors are significantly different across LMICs in both magnitude and secular trend. Improved stroke surveillance and care, as well as better management of the underlying risk factors, primarily undetected or uncontrolled high blood pressure (HBP) are needed.

Item Type: Article
Uncontrolled Keywords: secular trends,low- and middle-income countries, World Bank regions
Subjects: B900 Others in Subjects allied to Medicine
L400 Social Policy
Department: Faculties > Engineering and Environment > Mathematics, Physics and Electrical Engineering
Depositing User: Ay Okpokam
Date Deposited: 12 Apr 2016 12:07
Last Modified: 01 Aug 2021 02:41

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