Targeting the lung using siRNA and antisense based oligonucleotides

Moschos, Sterghios, Spinks, Karen, Williams, Andrew Evan and Lindsay, Mark (2008) Targeting the lung using siRNA and antisense based oligonucleotides. Current Pharmaceutical Design, 14 (34). pp. 3620-3627. ISSN 1381-6128

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Abstract

The accessibility to topical administration through inhalation, combined with its large surface area, has led to speculation that the lung might offer an ideal target for the application of oligonucleotide based therapeutics. In this review, we shall critically examine the challenges facing antisense and siRNA based approaches for target validation in vivo and as potential therapeutics. In particular, we shall discuss the antisense and siRNA based approaches in relation to factors such as delivery, distribution, stability, off-target effects, unwanted immune responses and the selection of the optimum mRNA targets.

Item Type:	Article
Subjects:	A300 Clinical Medicine B200 Pharmacology, Toxicology and Pharmacy C700 Molecular Biology, Biophysics and Biochemistry
Department:	Faculties > Health and Life Sciences > Applied Sciences
Depositing User:	Sterghios Moschos
Date Deposited:	24 Oct 2016 10:30
Last Modified:	12 Oct 2019 17:31
URI:	http://nrl.northumbria.ac.uk/id/eprint/28141

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