MicroRNA Biotherapeutics: Key Challenges from a Drug Development Perspective

Moschos, Sterghios (2013) MicroRNA Biotherapeutics: Key Challenges from a Drug Development Perspective. In: Biotherapeutics: Recent Developments using Chemical and Molecular Biology. RSC, pp. 176-223. ISBN 978-1-84973-601-5

Full text not available from this repository.

Abstract

The endogenous mediators of RNAi, microRNA (miRNAs), have grown in our understanding to be nodal elements in molecular homeostasis. Deregulation of miRNA levels is now believed to frequently cause disease. Considerable excitement therefore surrounds efforts focusing on restoring aberrant miRNA expression as a novel approach to therapy. In Chapter 7, the current body of knowledge around miRNA function in man and clinically relevant laboratory species is critically assessed from a miRNA biotherapeutics safety and efficacy perspective. In addition, the major relevant lessons learnt from RNAi and antisense drug development efforts are discussed where these translate to the field of miRNA therapy. Special attention is paid to key elements, such as evolutionarily optimized, viral vectoring solutions and genomic organization contexts that can be exploited for tailoring ectopic miRNA expression, maturation and bioprocessing. Moreover, the knowledge gaps arising from common approaches used to interrogate miRNA mode of action are identified in support of developing robust clinical path strategies in the personalized, precision medicine era.

Item Type:	Book Section
Subjects:	B200 Pharmacology, Toxicology and Pharmacy
Department:	Faculties > Health and Life Sciences > Applied Sciences
Depositing User:	Paul Burns
Date Deposited:	01 Nov 2016 17:49
Last Modified:	12 Oct 2019 18:28
URI:	http://nrl.northumbria.ac.uk/id/eprint/28354

Downloads