Castagnolo, Daniele, Bass, Rosemary, Jenkinson, Sarah, Wright, Jennifer, Smulders-Srinivasan, Tora and Marshall, Jamie (2017) Synthesis and biological evaluation of novel amidinourea and triazine congeners as inhibitors of MDA-MB-231 human breast cancer cell proliferation. ChemMedChem, 12 (4). pp. 288-291. ISSN 1860-7179
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Abstract
A series of novel amidinourea derivatives has been synthesised and the new compounds have been evaluated as inhibitors of MDA-MB-231 human breast cancer cell proliferation. In addition, a second series of triazine derivatives designed as rigid congeners of the amidinoureas was synthesised as well and the compounds were evaluated for their antiproliferative activity. Among the two series, the amidinourea 3d emerged as a potent anticancer hit compound with IC50 = 0.76 micormolar comparable to tamoxifen.
| Item Type: | Article |
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| Uncontrolled Keywords: | amidinourea, triazine, breast cancer, MDA-MB-231 cells, cell proliferation |
| Subjects: | C700 Molecular Biology, Biophysics and Biochemistry |
| Department: | Faculties > Health and Life Sciences > Applied Sciences |
| Depositing User: | Becky Skoyles |
| Date Deposited: | 19 Jan 2017 13:10 |
| Last Modified: | 01 Aug 2021 08:19 |
| URI: | http://nrl.northumbria.ac.uk/id/eprint/29228 |
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