MDMA polydrug users show process-specific central executive impairments coupled with impaired social and emotional judgement processes

Reay, Jonathon, Kennedy, David, Hamilton, Colin and Scholey, Andrew (2006) MDMA polydrug users show process-specific central executive impairments coupled with impaired social and emotional judgement processes. Journal of Psychopharmacology, 20 (3). pp. 385-388. ISSN 0269-8811

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Abstract

In recent years working memory de.cits have been reported in users of MDMA (3,4-methylenedioxymethamphetamine, ecstasy). The current study aimed to assess the impact of MDMA use on three separate central executive processes (set shifting, inhibition and memory updating) and also on ëprefrontalí mediated social and emotional judgement processes. Fifteen polydrug ecstasy users and 15 polydrug non-ecstasy user controls completed a general drug use questionnaire, the Brixton Spatial Anticipation task (set shifting), Backward Digit Span procedure (memory updating), Inhibition of Return (inhibition), an emotional intelligence scale, the Tromso Social Intelligence Scale and the Dysexecutive Questionnaire (DEX). Compared with MDMA-free polydrug controls, MDMA polydrug users showed impairments in set shifting and memory updating, and also in social and emotional judgement processes. The latter two de.cits remained signi.cant after controlling for other drug use. These data lend further support to the proposal that cognitive processes mediated by the prefrontal cortex may be impaired by recreational ecstasy use.

Item Type:	Article
Subjects:	B200 Pharmacology, Toxicology and Pharmacy C800 Psychology
Department:	Faculties > Health and Life Sciences > Psychology
Depositing User:	EPrint Services
Date Deposited:	10 Dec 2008 09:30
Last Modified:	10 Oct 2019 22:18
URI:	http://nrl.northumbria.ac.uk/id/eprint/2948

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