An Overview of Multifunctional Metal Chelators as Potential Treatments for Neurodegenerative Diseases

Lewis, Frank and Tetard, David (2017) An Overview of Multifunctional Metal Chelators as Potential Treatments for Neurodegenerative Diseases. In: Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics. Elsevier, San Diego, pp. 399-414. ISBN 978-0-12-804562-6

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Despite their ever increasing societal burden, neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease receive far less funding than other chronic diseases such as cancer, heart disease and stroke. Metal chelators have been recently proposed as treatments for these conditions due to the early involvement of mis-placed iron, copper and zinc in disease progression. However, due to the complex and multifactorial nature of disease pathogenesis, drugs with metal chelation as their only mode of action may not be sufficient to slow or stop disease progression. Thus multifunctional drugs with more than one mode of action besides metal chelation have been recently proposed as more promising treatments for these conditions. In this chapter, we provide a brief overview of the development of these multifunctional metal chelators, as well as the parent metal chelators on which these drugs are based.

Item Type: Book Section
Uncontrolled Keywords: metal chelator; Alzheimer's; drug; Parkinson's; iron; treatment; copper; multifunctional; zinc
Subjects: A100 Pre-clinical Medicine
A300 Clinical Medicine
B200 Pharmacology, Toxicology and Pharmacy
F100 Chemistry
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Frank Lewis
Date Deposited: 09 May 2017 08:10
Last Modified: 12 Oct 2019 18:31

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