Toll-like receptors in ocular surface disease

Redfern, Rachel and McDermott, Alison (2010) Toll-like receptors in ocular surface disease. Experimental Eye Research, 90 (6). pp. 679-687. ISSN 0014-4835

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Abstract

The ability of the ocular surface to mount an immune response is in part attributed to a family of proteins called toll-like receptors (TLRs). The latter are evolutionary conserved receptors that recognize and respond to various microbes and endogenous ligands. In addition to their recognition function, TLR activation triggers a complex signal transduction cascade that induces the production of inflammatory cytokines and co-stimulatory molecules, thus initiating innate and adaptive immunity. Toll-like receptor expression at the ocular surface is modulated during infection (e.g. Herpes simplex, bacterial keratitis and fungal keratitis) as well as during various inflammatory conditions (allergic conjunctivitis and dry-eye syndrome). Here recent findings regarding TLR expression and their involvement in various ocular surface diseases are discussed.

Item Type:	Article
Uncontrolled Keywords:	toll-like receptors; cornea; conjunctiva; inflammation; infection
Subjects:	B500 Ophthalmics
Department:	Faculties > Health and Life Sciences > Applied Sciences
Depositing User:	Becky Skoyles
Date Deposited:	23 May 2017 14:15
Last Modified:	12 Oct 2019 18:26
URI:	http://nrl.northumbria.ac.uk/id/eprint/30809

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