Henderson, John and O'Reilly, Steven (2017) Inflammasome lights up in systemic sclerosis. Arthritis Research & Therapy, 19 (1). p. 205. ISSN 1478-6362
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Official URL: https://doi.org/10.1186/s13075-017-1420-z
Abstract
Systemic sclerosis (SSc) is a pro-fibrotic condition with a poorly understood aetiology. Evidence presented by Artlett et al. in this issue suggests that the microRNA miR-155 is key, with its involvement dependent on the NLRP3 inflammasome. This links epigenetic events with inflammasome signalling in SSc and opens the door to new therapeutic strategies for the treatment of SSc.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Sclerosis, Fibrosis, Inflammasome, microRNA, Epigenetics, Interleukin-1, Caspase-1, MCC950 |
| Subjects: | C400 Genetics |
| Department: | Faculties > Health and Life Sciences > Applied Sciences |
| Depositing User: | Becky Skoyles |
| Date Deposited: | 05 Oct 2017 13:29 |
| Last Modified: | 13 Aug 2021 10:43 |
| URI: | http://nrl.northumbria.ac.uk/id/eprint/32204 |
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