Observational study of lung transplant recipients surviving 20 years

Sithamparanathan, Sasiharan, Thirugnanasothy, Logan, Clark, Stephen, Dark, John, Fisher, Andrew, Gould, Kate, Hasan, Asif, Lordan, James, Meachery, Gerard, Parry, Gareth and Corris, Paul (2016) Observational study of lung transplant recipients surviving 20 years. Respiratory Medicine, 117. pp. 103-108. ISSN 0954-6111

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Abstract

Background - Lung transplant recipients have reduced long-term survival compared with other solid organ recipients. There is a lack of published data on the characteristics of very long term survivors.

Methods - We describe the demographics, clinical history and post-procedure function of all lung transplant recipients who have survived greater than 20 years at our centre.

Results - At the time of analysis there were 21 (16.4%) of 128 patients who survived over 20 years. The mean age at transplantation was 31.8 ± 9.9 years. Five of 21 had undergone single-lung, eight double-lung and eight heart-lung transplant procedures. At the last evaluation, mean percentage predicted FEV1 in recipients of single and double lung were 51.3% and 57.9% respectively. By 20 years, 19 (90.5%) patients had developed bronchiolitis obliterans syndrome (BOS) with three (14%) BOS 1, six (29%) BOS 2 and 10 (48%) BOS 3 and two (9.5%) free from BOS. The median time to onset of BOS was 9.7 years (range 1.6–17.9). Of eight patients (38%) who required renal replacement, four (19%) had successfully undergone renal transplantation and four (19%) were on haemodialysis. Only one patient (5%) had symptomatic osteoporosis. Nineteen patients (90%) were treated for hypertension. Five patients (24%) had diabetes, all with an underlying diagnosis of cystic fibrosis and four of them developing diabetes post operatively.

Conclusions - In our experience, 20-year survivors of lung transplantation had a delayed onset of BOS and morbidities due to immunosuppression that can be appropriately managed leading to long-term survival.

Item Type:	Article
Uncontrolled Keywords:	Lung transplantation, Survival, Medical complications
Subjects:	B100 Anatomy, Physiology and Pathology
Department:	Faculties > Health and Life Sciences > Applied Sciences
Depositing User:	Becky Skoyles
Date Deposited:	29 Nov 2017 08:51
Last Modified:	12 Oct 2019 12:03
URI:	http://nrl.northumbria.ac.uk/id/eprint/32683

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