Serum Angiopoietin-2 and CRP Levels During COPD Exacerbations

Nikolakopoulou, Sofia, Hillas, Georgios, Perrea, Despina, Tentolouris, Nikolaos, Loukides, Stylianos, Kostikas, Konstantinos, Camargo Madeira Simoes, Davina, Georgakopoulou, Erasmia, Vogiatzakis, Evaggelos, Veldekis, Dimitrios and Bakakos, Petros (2014) Serum Angiopoietin-2 and CRP Levels During COPD Exacerbations. COPD: Journal of Chronic Obstructive Pulmonary Disease, 11 (1). pp. 46-51. ISSN 1541-2555

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Abstract

Background and Objective: Angiopoietin-2 (Ang-2) is an important mediator of angiogenesis and has been implicated in many inflammatory diseases. COPD is characterized by systemic inflammation, which is enhanced during exacerbations and may be assessed by measuring serum C-reactive protein (CRP). The aim of the study was to evaluate serum CRP and Ang-2 levels on the first (D1) and seventh day (D7) of hospitalization due to a COPD exacerbation and to examine possible associations of CRP and Ang-2 levels and kinetics with the length of hospital stay and outcome. Methods: We conducted a prospective study and evaluated 90 patients admitted to the hospital with a diagnosis of an acute exacerbation of COPD. A venous blood sample was obtained from all patients on D1 and D7 of hospitalization, for the measurement of Ang-2 and CRP. Results: Serum Ang-2 levels were significantly higher on D1 compared to D7 during the course of COPD exacerbation (p < 0.001). Serum CRP levels were also significantly higher on D1 compared to D7 (p < 0.001). Serum Ang-2 presented a significant positive correlation with CRP levels both on D1 and D7 (r = 0.315 and r = 0.228, respectively). Patients with unfavorable outcome had significantly higher Ang-2 levels both on D1 (p = 0.04) and D7 (p = 0.01). Conclusions: Serum Ang-2 levels are elevated at the onset of COPD exacerbations and are positively associated with CRP levels. Ang-2 levels decrease during the course of COPD exacerbations in patients with favorable outcome. Serum Ang-2 may serve as a biomarker that could predict the outcome of a COPD exacerbation.

Item Type:	Article
Uncontrolled Keywords:	Angiopoietin-2, CRP, inflammation, exacerbation, biomarkers
Subjects:	B100 Anatomy, Physiology and Pathology
Department:	Faculties > Health and Life Sciences > Sport, Exercise and Rehabilitation
Depositing User:	Becky Skoyles
Date Deposited:	07 Dec 2017 16:08
Last Modified:	12 Oct 2019 12:01
URI:	http://nrl.northumbria.ac.uk/id/eprint/32761

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