Collins, Gary, Ogundimu, Emmanuel and Altman, Douglas (2016) Sample size considerations for the external validation of a multivariable prognostic model: a resampling study. Statistics in Medicine, 35 (2). pp. 214-226. ISSN 0277-6715
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Abstract
After developing a prognostic model, it is essential to evaluate the performance of the model in samples independent from those used to develop the model, which is often referred to as external validation. However, despite its importance, very little is known about the sample size requirements for conducting an external validation. Using a large real data set and resampling methods, we investigate the impact of sample size on the performance of six published prognostic models. Focussing on unbiased and precise estimation of performance measures (e.g. the c‐index, D statistic and calibration), we provide guidance on sample size for investigators designing an external validation study. Our study suggests that externally validating a prognostic model requires a minimum of 100 events and ideally 200 (or more) events.
Item Type: | Article |
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Uncontrolled Keywords: | prognostic model, sample size, external validation |
Subjects: | G300 Statistics |
Department: | Faculties > Engineering and Environment > Mathematics, Physics and Electrical Engineering |
Depositing User: | Becky Skoyles |
Date Deposited: | 25 May 2018 12:01 |
Last Modified: | 01 Aug 2021 08:02 |
URI: | http://nrl.northumbria.ac.uk/id/eprint/34373 |
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