Human topoisomerase IIalpha and IIbeta interact with the C-terminal region of p53

Cowell, Ian, Okorokov, Andrei, Cutts, Sarah, Padget, Kay, Bell, Margaret, Milner, Jo and Austin, Caroline (2000) Human topoisomerase IIalpha and IIbeta interact with the C-terminal region of p53. Experimental Cell Research, 255 (1). pp. 86-94. ISSN 0014-4827

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The p53 tumor suppressor protein is a critical regulator of cell cycle progression and apoptosis following exposure of cells to DNA damaging agents such as ionizing radiation or anticancer drugs. An important group of anticancer drugs, including compounds such as etoposide and doxorubicin (Adriamycin), interacts with DNA topoisomerase II (topo II), causing the accumulation of enzyme-DNA adducts that ultimately lead to double-strand breaks and cell death via apoptosis. Human topo IIbeta has previously been shown to interact with p53, and we have extended this analysis to show that both topo IIalpha and IIbeta interact with p53 in vivo and in vitro. Furthermore, we show that the regulatory C-terminal basic region of p53 (residues 364-393) is necessary and sufficient for interaction with DNA topo II.

Item Type: Article
Uncontrolled Keywords: topoisomerase, p53, DNA repair, tumor suppressor, DNA damage
Subjects: C700 Molecular Biology, Biophysics and Biochemistry
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Kay Padget
Date Deposited: 09 Jul 2018 15:37
Last Modified: 11 Oct 2019 20:00

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