Folate and DNA methylation duringin uterodevelopment and aging

McKay, Jill, Williams, Elizabeth and Mathers, John (2004) Folate and DNA methylation duringin uterodevelopment and aging. Biochemical Society Transactions, 32 (6). pp. 1006-1007. ISSN 0300-5127

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Abstract

DNA methylation is one of several epigenetic mechanisms that play a regulatory role in genome programming and imprinting during embryogenesis. Aberrant DNA methylation has been implicated in the pathogenesis of a number of diseases associated with aging, including cancer and cardiovascular and neurological diseases. Evidence is accumulating that dietary factors in utero modulate disease risk in later life. Although folic acid is a key component of DNA methylation, the impact of folic acid availability in utero on DNA methylation patterns and disease risk in adulthood is at present poorly characterized. This review describes the relationship between folic acid and DNA methylation, and the association between DNA methylation during in utero development and aging.

Item Type:	Article
Subjects:	C700 Molecular Biology, Biophysics and Biochemistry
Department:	Faculties > Health and Life Sciences > Applied Sciences
Depositing User:	Becky Skoyles
Date Deposited:	19 Jul 2018 15:14
Last Modified:	11 Oct 2019 19:45
URI:	http://nrl.northumbria.ac.uk/id/eprint/35060

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