Assessement of quadriceps strength, endurance and fatigue in FSHD and CMT: Benefits and limits of femoral nerve magnetic stimulation

Bachasson, Damien, Temesi, John, Bankole, C., Lagrange, E., Boutte, C., Millet, Guillaume, Verges, Samuel, Levy, Patrick, Feasson, Leonard and Wuyam, Bernard (2014) Assessement of quadriceps strength, endurance and fatigue in FSHD and CMT: Benefits and limits of femoral nerve magnetic stimulation. Clinical Neurophysiology, 125 (2). pp. 396-405. ISSN 1388-2457

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Abstract

Objectives
To (i) evaluate the feasibility and the reliability of a test assessing quadriceps strength, endurance and fatigue in patients with fascioscapulohumeral dystrophy (FSHD) and Charcot-Marie-Tooth disease (CMT), (ii) compare quadriceps function between patients and healthy controls.

Methods
Controls performed the test once and patients twice on two separate visits. It involved progressive sets of 10 isometric contractions each followed by neuromuscular assessments with FNMS.

Results
Volitional assessment of muscle strength, endurance and fatigue appeared to be reliable in FSHD and CMT patients. Supramaximal FNMS was achieved in ∼70% of FSHD patients and in no CMT patients. In FSHD patients, Femoral nerve magnetic stimulation (FNMS) provided reliable assessment of central (typical error as a coefficient of variation (CVTE) < 8% for voluntary activation) and peripheral (CVTE < 10% and intraclass coefficient correlation >0.85 for evoked responses) function. Patients and controls had similar reductions in evoked quadriceps responses, voluntary activation and similar endurance.

Conclusions
This test provides reliable evaluation but FNMS exhibits limitations due to insufficient stimulation intensity particularly in neurogenic conditions. It showed similar central and peripheral quadriceps fatigability in patients and controls.

Significance
This test may be a valuable tool for patient follow-up although further development of magnetic stimulation devices is needed to extend its applicability.

Item Type:	Article
Uncontrolled Keywords:	Fascioscapulohumeral dystrophy, Charcot-Marie-Tooth disease, Hereditary motor and sensory neuropathy, Femoral magnetic nerve stimulation, Muscle strength, Muscle fatigue, Muscle endurance, Neuromuscular diseases, Experienced fatigue
Subjects:	B100 Anatomy, Physiology and Pathology C600 Sports Science
Department:	Faculties > Health and Life Sciences > Sport, Exercise and Rehabilitation
Depositing User:	Becky Skoyles
Date Deposited:	14 Sep 2018 14:43
Last Modified:	10 Oct 2019 21:16
URI:	http://nrl.northumbria.ac.uk/id/eprint/35731

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