DiSCUS: A Simulation Platform for Conjugation Computing

Goñi-Moreno, Angel and Amos, Martyn (2015) DiSCUS: A Simulation Platform for Conjugation Computing. In: Unconventional Computation and Natural Computation. Lecture Notes in Computer Science, 9252 . Springer, pp. 181-191. ISBN 978-3-319-21818-2

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Official URL: http://dx.doi.org/10.1007/978-3-319-21819-9_13


In bacterial populations, cells are able to cooperate in order to yield complex collective functionalities. Interest in population-level cellular behaviour is increasing, due to both our expanding knowledge of the underlying biological principles, and the growing range of possible applications for engineered microbial consortia. The ability of cells to interact through small signalling molecules (a mechanism known as quorum sensing) is the basis for the majority of existing engineered systems. However, horizontal gene transfer (or conjugation) offers the possibility of cells exchanging messages (using DNA) that are much more information-rich. The potential of engineering this conjugation mechanism to suit specific goals will guide future developments in this area. Motivated by a lack of computational models for examining the specific dynamics of conjugation, we present a simulation framework for its further study.

Item Type: Book Section
Uncontrolled Keywords: Graphic Processing Unit, Horizontal Gene Transfer, Microbial Consortium, Simulation Platform, Modular Fashion
Subjects: G400 Computer Science
Department: Faculties > Engineering and Environment > Computer and Information Sciences
Depositing User: Becky Skoyles
Date Deposited: 18 Sep 2018 15:23
Last Modified: 11 Oct 2019 19:15
URI: http://nrl.northumbria.ac.uk/id/eprint/35772

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