Evaluating cellular uptake of gold nanoparticles in HL-7702 and HepG2 cells for plasmonic photothermal therapy

Wang, Peng, Wu, Qiang, Wang, Fuyan, Zhang, Yaping, Jiang, Tao, Gu, Chenjie, Huang, Shuiping, Wang, Hongxi, Bu, Shizhong and Zhou, Jun (2018) Evaluating cellular uptake of gold nanoparticles in HL-7702 and HepG2 cells for plasmonic photothermal therapy. Nanomedicine, 13 (18). pp. 2245-2259. ISSN 1743-5889

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Abstract

A novel method is proposed for quantifying the Raman intensity as a function of gold mass in a single cell based on the Raman mapping and inductively coupled plasma-mass spectrometry techniques. And a high-efficiency plasmonic photothermal therapy has also been achieved by adjusting the laser wavelength, laser power and exposure time, resulting in most of the HL-7702 cells survive, whereas most of the HepG2 cells get damaged.

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