Functionalized core/shell nanofibers for the differentiation of mesenchymal stem cells for vascular tissue engineering

Ezhilarasu, Hariharan, Sadiq, Asif, Ratheesh, Greeshma, Sridhar, Sreepathy, Ramakrishna, Seeram, Ab. Rahim, Mohd Hasbi, Yusoff, Mashitah, Jose, Rajan and Reddy, Venugopal (2019) Functionalized core/shell nanofibers for the differentiation of mesenchymal stem cells for vascular tissue engineering. Nanomedicine, 14 (2). pp. 201-214. ISSN 1743-5889

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Abstract

Aim: Atherosclerosis is a common cardiovascular disease causing medical problems globally leading to coronary artery bypass surgery. The present study is to fabricate core/shell nanofibers to encapsulate VEGF for the differentiation of mesenchymal stem cells (MSCs) into smooth muscle cells to develop vascular grafts. Materials & methods: The fabricated core/shell nanofibers contained polycaprolactone/gelatin as the shell, and silk fibroin/VEGF as the core materials. Results: The results observed that the core/shell nanofibers interact to differentiate MSCs into smooth muscle cells by the expression of vascular smooth muscle cell (VSMC) contractile proteins α-actinin, myosin and F-actin. Conclusion: The functionalized polycaprolactone/gelatin/silk fibroin/VEGF (250 ng) core/shell nanofibers were fabricated for the controlled release of VEGF in a persistent manner for the differentiation of MSCs into smooth muscle cells for vascular tissue engineering.

Item Type:	Article
Uncontrolled Keywords:	α-actinin, core/shell nanofibers, gelatin, mesenchymal stem cells, myosin, polymers, silk fibroin, smooth muscle cells, vascular tissue engineering, VEGF
Subjects:	C900 Others in Biological Sciences
Department:	Faculties > Engineering and Environment > Mechanical and Construction Engineering
Depositing User:	Becky Skoyles
Date Deposited:	29 Jan 2019 11:56
Last Modified:	10 Oct 2019 19:00
URI:	http://nrl.northumbria.ac.uk/id/eprint/37783

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