Fibrosis and Cirrhosis Reversibility – Molecular Mechanisms

Gieling, Roben, Burt, Alastair D. and Mann, Derek A. (2008) Fibrosis and Cirrhosis Reversibility – Molecular Mechanisms. Clinics in Liver Disease, 12 (4). pp. 915-937. ISSN 1089-3261

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Abstract

The concept that liver fibrosis is a dynamic process with potential for regression as well as progression has emerged in parallel with clinical evidence for remodeling of fibrotic extracellular matrix in patients who can be effectively treated for their underlying cause of liver disease. This article reviews recent discoveries relating to the cellular and molecular mechanisms that regulate fibrosis regression, with emphasis on studies that have used experimental in vivo models of liver disease. Apoptosis of hepatic myofibroblasts is discussed. The functions played by transcription factors, receptor-ligand interactions, and cell-matrix interactions as regulators of the lifespan of hepatic myofibroblasts are considered, as are the therapeutic opportunities for modulating these functions. Growth factors, proteolytic enzymes, and their inhibitors are discussed in detail.

Item Type:	Article
Uncontrolled Keywords:	Hepatic myofibroblasts; Apoptosis; NF-κB; Fibrosis; Extracellular matrix; Neovascularisation
Subjects:	A300 Clinical Medicine
Department:	Faculties > Health and Life Sciences > Applied Sciences
Depositing User:	Paul Burns
Date Deposited:	13 Feb 2019 16:07
Last Modified:	10 Oct 2019 23:46
URI:	http://nrl.northumbria.ac.uk/id/eprint/37975

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