A Rapid Synthetic Approach to the ABCD Core of the Stemona Alkaloids

Connelly, Rickki L., Knowles, Jonathan P. and Booker-Milburn, Kevin I. (2019) A Rapid Synthetic Approach to the ABCD Core of the Stemona Alkaloids. Organic Letters, 21 (1). pp. 18-21. ISSN 1523-7060

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Official URL: http://dx.doi.org/10.1021/acs.orglett.8b03371


A new Lewis acid-assisted Brønsted acid cascade approach for the stereoselective formation of the tetracyclic Stemona alkaloid skeleton is described in five steps from epoxide 15. Crucially, this tetracyclic product can be accessed as either C13 epimer, potentially serving as intermediates for the synthesis of a range of Stemona alkaloids.

Item Type: Article
Subjects: F100 Chemistry
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Paul Burns
Date Deposited: 22 Feb 2019 11:43
Last Modified: 31 Jul 2021 20:19
URI: http://nrl.northumbria.ac.uk/id/eprint/38200

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