Bowerbank, Samantha, Carlin, Michelle and Dean, John (2019) Dissolution Testing of Single- and Dual-Component Thyroid Hormone Supplements. Separations, 6 (1). p. 18. ISSN 2297-8739
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Abstract
A method for the analysis of thyroid hormones by liquid chromatography-mass spectrometry was used for the dissolution testing of single- and dual-component thyroid hormone supplements via a two-stage biorelevant dissolution procedure. The biorelevant media consisted of fasted-state simulated gastric fluid and fasted state simulated intestinal fluid at 37 °C, and was investigated using an internationally recognized protocol. The dissolution profiles showed consistent solubilization for both single- and dual-component batches at pH 6.5 in the fasted-state simulated intestinal fluid.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | thyroid, dissolution, liquid chromatography-mass spectrometry |
| Subjects: | B800 Medical Technology C700 Molecular Biology, Biophysics and Biochemistry |
| Department: | Faculties > Health and Life Sciences > Applied Sciences |
| Depositing User: | Paul Burns |
| Date Deposited: | 04 Apr 2019 10:57 |
| Last Modified: | 01 Aug 2021 12:18 |
| URI: | http://nrl.northumbria.ac.uk/id/eprint/38743 |
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