Ramdhan, Nikhil Doorvesh, Blom, Jochen, Sutcliffe, Iain, Pereira-Ribeiro, Paula Marcele Afonso, Santos, Cintia Silva, Mattos-Guaraldi, Ana Luiza, Burkovski, Andreas and Sangal, Vartul (2019) Genomic analysis of a novel nontoxigenic Corynebacterium diphtheriae strain isolated from a cancer patient. New Microbes and New Infections, 30. p. 100544. ISSN 2052-2975
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Genomic analysis of a novel nontoxigenic Corynebacterium diphtheriae strain isolated from a cancer patient.pdf - Published Version Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. Download (156kB) | Preview |
Abstract
The genome of a novel nontoxigenic Corynebacterium diphtheriae, strain 5015, isolated from a patient with adenoid cystic carcinoma was sequenced and compared with 117 publically available genomes. This strain is phylogenetically distinct and lacks virulence genes encoding the toxin, BigA and Sdr-like adhesins. Strain 5015 possesses spaD-type and spaH-type pilus gene clusters with a loss of some gene functions, and 31 unique genes that need molecular characterization to understand their potential role in virulence characteristics.
| Item Type: | Article |
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| Uncontrolled Keywords: | Adenoid cystic carcinoma, Corynebacterium diphtheriae, invasive infection, nontoxigenic, virulence |
| Subjects: | A300 Clinical Medicine C700 Molecular Biology, Biophysics and Biochemistry |
| Department: | Faculties > Health and Life Sciences > Applied Sciences |
| Depositing User: | Elena Carlaw |
| Date Deposited: | 29 Apr 2019 15:02 |
| Last Modified: | 01 Aug 2021 11:49 |
| URI: | http://nrl.northumbria.ac.uk/id/eprint/39099 |
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