O'Reilly, Steven and van Laar, Jacob M. (2018) Targeting the TLR4–MD2 axis in systemic sclerosis. Nature Reviews Rheumatology, 14 (10). pp. 564-566. ISSN 1759-4790
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Official URL: https://doi.org/10.1038/s41584-018-0077-6
Abstract
Inappropriate activation of Toll-like receptor 4 (TLR4) on resident fibroblasts, through the binding of damage-associated molecular patterns, is a potential driver of fibrosis in systemic sclerosis. New evidence suggests that targeting fibroblast-specific TLR4 or an accessory molecule MD2 could have therapeutic value.
| Item Type: | Article |
|---|---|
| Subjects: | B200 Pharmacology, Toxicology and Pharmacy |
| Department: | Faculties > Health and Life Sciences > Applied Sciences |
| Depositing User: | Elena Carlaw |
| Date Deposited: | 02 May 2019 14:49 |
| Last Modified: | 10 Oct 2019 16:19 |
| URI: | http://nrl.northumbria.ac.uk/id/eprint/39157 |
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