Acute and chronic effects of exercise on the kynurenine pathway in humans – A brief review and future perspectives

Metcalfe, Alan, Koliamitra, Christina, Javelle, Florian, Bloch, Wilhelm and Zimmer, Philipp (2018) Acute and chronic effects of exercise on the kynurenine pathway in humans – A brief review and future perspectives. Physiology & Behavior, 194. pp. 583-587. ISSN 0031-9384

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Abstract

Tryptophan (TRP) is an essential amino acid. Metabolites of TRP have been identified as important mediators in immune regulation and function of the central nervous system. Inflammation strongly stimulates to the breakdown of TRP into Kynurenine (KYN), representing the initial step of the KYN pathway. Recently, exercise interventions have been able to demonstrate a modification of the KYN pathway plausibly by altering inflammation. However, modifications differ between acute and chronic exercise interventions. As such, this review examines the current studies that have investigated the effect of an acute (single bout) or chronic (training) exercise intervention on levels of TRP and KYN in both healthy and diseased populations.

Item Type:	Article
Uncontrolled Keywords:	Exercise, Tryptophan, Physiology, Immunology
Subjects:	C800 Psychology
Department:	Faculties > Health and Life Sciences > Sport, Exercise and Rehabilitation
Depositing User:	Elena Carlaw
Date Deposited:	10 May 2019 11:07
Last Modified:	10 Oct 2019 19:15
URI:	http://nrl.northumbria.ac.uk/id/eprint/39247

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