Model for a population-based microbial oscillator

Goñi-Moreno, Angel and Amos, Martyn (2011) Model for a population-based microbial oscillator. Biosystems, 105 (3). pp. 286-294. ISSN 0303-2647

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Abstract

Genetic oscillators are a major theme of interest in the emerging field of synthetic biology. Until recently, most work has been carried out using intra-cellular oscillators, but this approach restricts the broader applicability of such systems. Motivated by a desire to develop large-scale, spatially distributed cell-based computational systems, we present an initial design for a population-level oscillator which uses three different bacterial strains. Our system is based on the client-server model familiar to computer science, and uses quorum sensing for communication between nodes. Importantly, it is robust to perturbation and noise. We present the results of extensive in silico simulation tests, which confirm the feasibility of our design.

Item Type:	Article
Uncontrolled Keywords:	Bacteria, Oscillator, Population, Simulation, Synthetic biology
Subjects:	C700 Molecular Biology, Biophysics and Biochemistry G400 Computer Science
Department:	Faculties > Engineering and Environment > Computer and Information Sciences
Depositing User:	Paul Burns
Date Deposited:	13 May 2019 11:47
Last Modified:	10 Oct 2019 19:01
URI:	http://nrl.northumbria.ac.uk/id/eprint/39288

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