Localized viscoelasticity measurements with untethered intravitreal microrobots

Pokki, Juho, Ergeneman, Olgac, Bergeles, Christos, Torun, Hamdi and Nelson, Bradley J. (2012) Localized viscoelasticity measurements with untethered intravitreal microrobots. In: EMBS 2012 - 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 28th August - 1st September 2012, San Diego, California.

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Abstract

Microrobots are a promising tool for medical interventions and micromanipulation. In this paper, we explore the concept of using microrobots for microrheology. Untethered magnetically actuated microrobots were used to characterize one of the most complex biofluids, the vitreous humor. In this work we began by experimentally characterizing the viscoelastic properties of an artificial vitreous humor. For comparison, its properties were also measured using special microcantilevers in an atomic force microscope (AFM) setup. Subsequently, an untethered device was used to study the vitreous humor of a porcine eye, which is a valid ex-vivo model of a human eye. Its viscoelasticity model was extracted, which was in agreement with the model of the artificial vitreous. The existing characterization methodology requires eye and vitreous humor dissection for the microrheology measurements. We envision that the method proposed here can be used in in vivo.

Item Type:	Conference or Workshop Item (Paper)
Uncontrolled Keywords:	Force, Elasticity, Viscosity, Probes, Magnetic resonance imaging, Magnetic separation, Magnetomechanical effects
Subjects:	B800 Medical Technology H600 Electronic and Electrical Engineering
Department:	Faculties > Engineering and Environment > Mathematics, Physics and Electrical Engineering
Depositing User:	Paul Burns
Date Deposited:	14 Jun 2019 14:31
Last Modified:	10 Oct 2019 18:02
URI:	http://nrl.northumbria.ac.uk/id/eprint/39704

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