Self-initiated physical activity is associated with high sensitivity C-reactive protein: A longitudinal study in 5,030 adults

Fernandes, Rômulo Araújo, Ritti-Dias, Raphael Mendes, Balagopal, P. Babu, Conceição, Raquel D.O., Santos, Raul D., Cucato, Gabriel and Bittencourt, Márcio Sommer (2018) Self-initiated physical activity is associated with high sensitivity C-reactive protein: A longitudinal study in 5,030 adults. Atherosclerosis, 273. pp. 131-135. ISSN 0021-9150

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BACKGROUND AND AIMS: Structured regular exercise programs decrease high-sensitivity C-reactive protein (hsCRP), a marker of low-grade inflammation in adults. Longitudinal effects of self-initiated physical activity levels (PAL) on hsCRP are less clear. This study evaluated the association of longitudinal changes in hsCRP in relation to modifications in PAL, over time, in a large sample of adults.

METHODS: Participants included 5030 adults, 4045 (80%) males, undergoing routine health screening examinations. Elevated level of hsCRP was defined as ≥3 mg/L. Self-reported PAL, height, weight, blood pressure and blood samples were collected at baseline and after a median of 2.9 years (P25th 1.97 and P75th 4.37 yrs). Participants were stratified according to their PAL at baseline and follow-up as: i) persistently physically inactive; ii) became physically inactive; iii) became physically active; iv) persistently physically active (active both at baseline and follow-up).

RESULTS: Persistently physically active participants had lower odds of having higher hsCRP (OR = 0.35 [95% CI: 0.25 to 0.48]). The maintenance of high PAL was associated with lower hsCRP in both sexes (men: OR = 0.44 [0.30 to 0.65] and women: OR = 0.35 [0.16 to 0.76]). Participants with overweight/obesity (OR = 0.43 [95% CI: 0.29 to 0.63]) and smokers (OR = 0.123 [95% CI: 0.03 to 0.60]) who were persistently active had lower odds of having higher hsCRP compared to physically inactive peers.

CONCLUSIONS: Self-initiated PAL was longitudinally associated with hsCRP in adults. The data suggest that the initiation or maintenance of PA attenuates the low-grade inflammatory state, independent of sex, body weight and smoking status.

Item Type: Article
Uncontrolled Keywords: Exercise, Body mass index, Cardiovascular risk, C reactive protein, Inflammation
Subjects: B100 Anatomy, Physiology and Pathology
B300 Complementary Medicine
B900 Others in Subjects allied to Medicine
Department: Faculties > Health and Life Sciences > Sport, Exercise and Rehabilitation
Depositing User: Elena Carlaw
Date Deposited: 20 Nov 2019 11:28
Last Modified: 20 Nov 2019 11:28

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