Iridium(iii) complexes of 1,2,4-triazines as potential bioorthogonal reagents: metal coordination facilitates luminogenic reaction with strained cyclooctynes

Kozhevnikov, Valery N., Deary, Michael, Mantso, Theodora, Panayiotidis, Mihalis I. and Sims, Mark T. (2019) Iridium(iii) complexes of 1,2,4-triazines as potential bioorthogonal reagents: metal coordination facilitates luminogenic reaction with strained cyclooctynes. Chemical Communications, 55 (95). pp. 14283-14286. ISSN 1359-7345

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Abstract

In this paper we describe unprecedented Ir(III) complexes of 5-(2-pyridyl)-1,2,4-triazine and their reactivity towards the strained cyclooctyne BCN. The coordination of a 1,2,4-triazine ring to an iridium(III) ion drastically increases the speed of the reaction, showing the second order rate constant of 8 M−1 s−1, the record value to date for a triazine-BCN reaction.

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