Is there an increased risk of perinatal mental disorder in women with gestational diabetes? A systematic review and meta‐analysis

Wilson, Claire A., Newham, James, Rankin, J., Ismail, K., Simonoff, Emily, Reynolds, R. M., Stoll, N. and Howard, L. M. (2020) Is there an increased risk of perinatal mental disorder in women with gestational diabetes? A systematic review and meta‐analysis. Diabetic Medicine, 37 (4). pp. 602-622. ISSN 0742-3071

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Abstract

Aim
Gestational diabetes (GDM) and mental disorder are common perinatal morbidities and are associated with adverse maternal and child outcomes. While there is a relationship between type 2 diabetes and mental disorder, the relationship between GDM and mental disorder has been less studied. We conducted a systematic review and meta‐analysis of the prevalence of mental disorders in women with GDM and their risk for mental disorders compared with women without GDM.

Methods
Published, peer‐reviewed literature measuring prevalence and/or odds of GDM and perinatal mental disorders was reviewed systematically. Risk of bias was assessed using a checklist. Two independent reviewers were involved. Analyses were grouped by stage of peripartum, i.e. antepartum at the time of GDM diagnosis and after diagnosis, and in the postpartum.

Results
Sixty‐two studies were included. There was an increased risk of depressive symptoms in the antenatal period around the time of diagnosis of GDM [odds ratio (OR) 2.08; 95% confidence interval (CI) 1.42, 3.05] and in the postnatal period (OR 1.59; 95% CI 1.26, 2.00).

Conclusions
Given the potential relationship between GDM and perinatal mental disorders, integration of physical and mental healthcare in women experiencing GDM and mental disorders could improve short‐ and long‐term outcomes for women and their children.

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