How do malaria parasites activate dendritic cells?

Lamb, Tracey, Schenk, Michael and Todryk, Stephen (2010) How do malaria parasites activate dendritic cells? Future Microbiology, 5 (8). pp. 1167-1171. ISSN 1746-0913

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Abstract

Malaria parasites induce strong proinflammatory immune responses upon infection. These responses, driven largely by CD4+ Th1 cells, help the body to control malaria parasitemia. When excessive, inflammatory responses contribute to the pathology observed in malaria infection. Dendritic cells (DCs) are innate immune cells that activate Th1 cells in malaria infection via the secretion of the cytokine IL-12. It remains unclear precisely which components of malaria-infected red blood cells are responsible for activating DCs. In this study, Wu et al. set out to deconstruct malaria-infected red blood cells to determine the immunogenic components that induce production of the proinflammatory cytokines IL-12 and TNF-α from DCs. The authors suggest that parasite DNA complexed with protein is the main trigger for activation of DCs in malaria-infected red blood cells.

Item Type:	Article
Uncontrolled Keywords:	malaria, T cells, immunity, dendritic cells
Subjects:	B900 Others in Subjects allied to Medicine C900 Others in Biological Sciences
Department:	Faculties > Health and Life Sciences > Applied Sciences
Depositing User:	Ay Okpokam
Date Deposited:	15 Dec 2011 15:36
Last Modified:	12 Oct 2019 18:26
URI:	http://nrl.northumbria.ac.uk/id/eprint/4188

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