Chappel, Lucy, Wong, Lai Chun, Leong, Chee-Onn, Mai, Chun-Wai, Meikle, Ian T., Stanforth, Stephen and Truong, Thang (2020) The synthesis of trifluoromethylated N-nitroaryl-2-amino-1,3-dichloropropane derivatives and their evaluation as potential anti-cancer agents. Bioorganic & Medicinal Chemistry Letters, 30 (4). p. 126910. ISSN 0960-894X
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Abstract
Six N-nitroaryl-2-amino-1,3-dichloropropane derivatives have been prepared and evaluated against 18 cancer cell lines and two non-cancerous cell lines. Analysis of cell viability data and IC50 values indicated that the presence of a trifluoromethyl group in the nitroaryl moiety is an important structural feature associated with the compounds’ cytotoxicities.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Nitroaromatic drugs, Anti-cancer agents, Trifluoromethylated drugs, Nitrogen mustards |
| Subjects: | A300 Clinical Medicine B200 Pharmacology, Toxicology and Pharmacy B900 Others in Subjects allied to Medicine |
| Department: | Faculties > Health and Life Sciences > Applied Sciences |
| Depositing User: | Elena Carlaw |
| Date Deposited: | 20 Jan 2020 14:59 |
| Last Modified: | 31 Jul 2021 14:17 |
| URI: | http://nrl.northumbria.ac.uk/id/eprint/41948 |
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