Significance of circadian rhythms in severely brain-injured patients

Blume, Christine, Lechinger, Julia, Santhi, Nayantara, Giudice, Renata del, Gnjezda, Maria-Teresa, Pichler, Gerald, Scarpatetti, Monika, Donis, Johann, Michitsch, Gabriele and Schabus, Manuel (2017) Significance of circadian rhythms in severely brain-injured patients. Neurology, 88 (20). pp. 1933-1941. ISSN 0028-3878

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Abstract

Objective: To investigate the relationship between the presence of a circadian body temperature rhythm and behaviorally assessed consciousness levels in patients with disorders of consciousness (DOC; i.e., vegetative state/unresponsive wakefulness syndrome or minimally conscious state).

Methods: In a cross-sectional study, we investigated the presence of circadian temperature rhythms across 6 to 7 days using external skin temperature sensors in 18 patients with DOC. Beyond this, we examined the relationship between behaviorally assessed consciousness levels and circadian rhythmicity.

Results: Analyses with Lomb-Scargle periodograms revealed significant circadian rhythmicity in all patients (range 23.5–26.3 hours). We found that especially scores on the arousal subscale of the Coma Recovery Scale–Revised were closely linked to the integrity of circadian variations in body temperature. Finally, we piloted whether bright light stimulation could boost circadian rhythmicity and found positive evidence in 2 out of 8 patients.

Conclusion: The study provides evidence for an association between circadian body temperature rhythms and arousal as a necessary precondition for consciousness. Our findings also make a case for circadian rhythms as a target for treatment as well as the application of diagnostic and therapeutic means at times when cognitive performance is expected to peak.

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