Gait Rather Than Cognition Predicts Decline in Specific Cognitive Domains in Early Parkinson’s Disease

Morris, Rosie, Lord, Sue, Lawson, Rachael, Coleman, Shirley, Galna, Brook, Duncan, Gordon, Khoo, Tien, Yarnall, Alison, Burn, David and Rochester, Lynn (2017) Gait Rather Than Cognition Predicts Decline in Specific Cognitive Domains in Early Parkinson’s Disease. The Journals of Gerontology: Series A, 72 (12). pp. 1656-1662. ISSN 1079-5006

Preview

Text glx071.pdf - Published Version Available under License Creative Commons Attribution 4.0. Download (451kB) | Preview

Abstract

Background: Dementia is significant in Parkinson’s disease (PD) with personal and socioeconomic impact. Early identification of risk is of upmost importance to optimize management. Gait precedes and predicts cognitive decline and dementia in older adults. We aimed to evaluate gait characteristics as predictors of cognitive decline in newly diagnosed PD.

Methods: One hundred and nineteen participants recruited at diagnosis were assessed at baseline, 18 and 36 months. Baseline gait was characterized by variables that mapped to five domains: pace, rhythm, variability, asymmetry, and postural control. Cognitive assessment included attention, fluctuating attention, executive function, visual memory, and visuospatial function. Mixed-effects models tested independent gait predictors of cognitive decline.

Results: Gait characteristics of pace, variability, and postural control predicted decline in fluctuating attention and visual memory, whereas baseline neuropsychological assessment performance did not predict decline.

Conclusions: This provides novel evidence for gait as a clinical biomarker for PD cognitive decline in early disease.

Actions (login required)

View Item

Downloads