Monoterpenoid extract of sage (Salvia lavandulaefolia) with cholinesterase inhibiting properties improves cognitive performance and mood in healthy adults

Kennedy, David, Dodd, Fiona, Robertson, Bernadette, Okello, Edward, Reay, Jonathon, Scholey, Andrew and Haskell, Crystal (2011) Monoterpenoid extract of sage (Salvia lavandulaefolia) with cholinesterase inhibiting properties improves cognitive performance and mood in healthy adults. Journal of Psychopharmacology, 25 (8). pp. 1088-1100. ISSN 0269-8811

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Abstract

Extracts of sage (Salvia officinalis/lavandulaefolia) with terpenoid constituents have previously been shown to inhibit cholinesterase and improve cognitive function. The current study combined an in vitro investigation of the cholinesterase inhibitory properties and phytochemical constituents of a S. lavandulaefolia essential oil, with a double-blind, placebo-controlled, balanced crossover study assessing the effects of a single dose on cognitive performance and mood. In this latter investigation 36 healthy participants received capsules containing either 50 mu L of the essential oil or placebo on separate occasions, 7 days apart. Cognitive function was assessed using a selection of computerized memory and attention tasks and the Cognitive Demand Battery before the treatment and 1-h and 4-h post-dose. The essential oil was a potent inhibitor of human acetylcholinesterase (AChE) and consisted almost exclusively of monoterpenoids. Oral consumption lead to improved performance of secondary memory and attention tasks, most notably at the 1-h post-dose testing session, and reduced mental fatigue and increased alertness which were more pronounced 4-h post-dose. These results extend previous observations of improved cognitive performance and mood following AChE inhibitory sage extracts and suggest that the ability of well-tolerated terpenoid-containing extracts to beneficially modulate cholinergic function and cognitive performance deserves further attention.

Item Type:	Article
Additional Information:	Crystal Haskell now known as Crystal Haskell-Ramsay.
Uncontrolled Keywords:	Acetylcholinesterase, attention, memory, monoterpenoid, mood, sage, salvia, Salvia lavandulaefolia
Subjects:	B900 Others in Subjects allied to Medicine C800 Psychology
Department:	Faculties > Health and Life Sciences > Psychology
Depositing User:	Ay Okpokam
Date Deposited:	16 Dec 2011 12:45
Last Modified:	10 Oct 2019 22:30
URI:	http://nrl.northumbria.ac.uk/id/eprint/4211

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