Gamba, Pamela, James, Katherine and Zenkin, Nikolay (2017) A link between transcription fidelity and pausing in vivo. Transcription, 8 (2). pp. 99-105. ISSN 2154-1264
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A link between transcription fidelity and pausing in vivo.pdf - Published Version Available under License Creative Commons Attribution. Download (515kB) | Preview |
Official URL: https://doi.org/10.1080/21541264.2016.1274812
Abstract
Pausing by RNA polymerase is a major mechanism that regulates transcription elongation but can cause conflicts with fellow RNA polymerases and other cellular machineries. Here, we summarize our recent finding that misincorporation could be a major source of transcription pausing in vivo, and discuss the role of misincorporation-induced pausing.
| Item Type: | Article |
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| Uncontrolled Keywords: | Collisions of transcription with replication, fidelity, Gre, misincorporation, pausing, proofreading, TFIIS, transcription |
| Subjects: | C400 Genetics C500 Microbiology C900 Others in Biological Sciences |
| Department: | Faculties > Health and Life Sciences > Applied Sciences |
| Depositing User: | John Coen |
| Date Deposited: | 09 Mar 2020 09:59 |
| Last Modified: | 31 Jul 2021 19:30 |
| URI: | http://nrl.northumbria.ac.uk/id/eprint/42408 |
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