Acute and chronic effects of multivitamin/mineral supplementation on objective and subjective energy measures

Dodd, Fiona, Kennedy, David, Stevenson, E. J., Veasey, Rachel, Walker, Karen, Reed, Stephen, Jackson, Philippa and Haskell-Ramsay, Crystal (2020) Acute and chronic effects of multivitamin/mineral supplementation on objective and subjective energy measures. Nutrition & Metabolism, 17 (1). p. 16. ISSN 1743-7075

s12986-020-00435-1.pdf - Published Version
Available under License Creative Commons Attribution 4.0.

Download (1MB) | Preview
Official URL:


Background: Vitamins and minerals play an essential role within many cellular processes including energy
production and metabolism. Previously, supplementation with a multivitamin/mineral (MVM) for ≥28 days resulted
in improvements to cognition and subjective state. We have also demonstrated shifts in metabolism during
cognitively demanding tasks following MVM in females, both acutely and following 8-week supplementation. The
current study aimed to assess these effects further in males and females using metabolically challenging exercise
and cognitive tasks.
Methods: The current randomised, placebo-controlled, parallel groups study investigated the effects of a MVM
complex in 82 healthy young (18-35y) exercisers. Subjective ratings and substrate metabolism were assessed during
30 min each of increasingly effortful incremental exercise and demanding cognitive tasks. Assessments took place
on acute study days following a single dose (Day 1) of MVM, containing 3 times recommended daily allowance of
water-soluble vitamins plus CoQ10, and following 4-week supplementation (Day 28).
Results: Energy expenditure (EE) was increased during cognitive tasks following MVM across Day 1 and Day 28,
with greater effects in males. In males, MVM also increased carbohydrate oxidation and energy expenditure during
exercise across Day 1 and Day 28. In females, mental tiredness was lower during exercise; increases in physical
tiredness following 30 min of exercise were attenuated; and stress ratings following cognitive tasks were reduced
following MVM. In males, MVM only lowered mental tiredness following 10 min of exercise. These effects were
apparent irrespective of day, but effects on mental tiredness were greater on Day 28. Ferritin levels were also higher
on Day 28 in those receiving MVM.
Conclusion: These findings extend on existing knowledge, demonstrating increased carbohydrate oxidation and
increased energy expenditure in males following MVM supplementation for the first time. Importantly, they show
modulation of energy expenditure and subjective tiredness following a single dose, providing further evidence for
acute effects of MVM. Differential effects in men and women suggest that sex may play an important role in the
effects of MVM on energy metabolism and should be considered in future research.
Trial registration:, NCT03003442. Registered 22nd November 2016 – retrospectively registered

Item Type: Article
Uncontrolled Keywords: Vitamin, Mineral, Coenzyme Q10, Cognitive, Metabolism, Indirect calorimetry, Energy expenditure, Exercise, Fatigue, Stress
Subjects: B200 Pharmacology, Toxicology and Pharmacy
B400 Nutrition
C800 Psychology
Department: Faculties > Health and Life Sciences > Psychology
Depositing User: Elena Carlaw
Date Deposited: 07 Apr 2020 15:08
Last Modified: 31 Jul 2021 18:34

Actions (login required)

View Item View Item


Downloads per month over past year

View more statistics